Given its central location on the map and its position on the Great Lakes, Illinois has been a long-time hub of America’s transportation system, which includes the relatively recent introduction of the Interstate Highway System.

Twelve primary (one- and two-digit) interstate routes pass through Illinois, the most of any state in the nation: Interstates 24, 39, 55, 57, 64, 70, 72, 74, 80, 88, 90 and 94. This extensive interstate network not only connects Illinois with relatively close cities such as, St. Louis, Des Moines and Milwaukee, but far-off locales such as, San Francisco, Seattle, Denver, Minneapolis, Baltimore and Boston. It also is possible to travel to all of Illinois’ neighbors solely by interstate highway.

Learn more:
The Interstate Guide is an extensive reference for the entire Interstate Highway System.
The Federal Highway Administration is the official site for the Interstate Highway System.